29 March 2017

09:00-09:30 Registration

GPCRdb and GPCRmd joint satellite meeting

09:00-09:35 Welcome and program go-through
David Gloriam, University of Copenhagen & Jana Selent, Pompeu Fabra University, Hospital del Mar Medical Research Institute

09:35-09:40 GPCRdb introduction
David Gloriam, University of Copenhagen

09:40-09:55 Crystallisation construct design tool
Christian Munk, University of Copenhagen

09:55-10:25 G protein data and tools & GPCR drugs and targets
Alexander Hauser, University of Copenhagen

10:25-10:45 Knime nodes for GPCRdb
Márton Vass, VU Amsterdam

10:45-10:50 Mutation design tool – update of new data
Kasper Harpsøe, University of Copenhagen

10:50-10:55 Structurally conserved TM helix bulges and constrictions
Janne Bibbe, Radboud University Medical Centre

10:55-11:10 Break and optional questions to presenters

11:10-11:30 GPCRmd database prototype demo
Jana Selent, Pompeu Fabra University, Hospital del Mar Medical Research Institute

11:30-11:45 Flare plots for dynamic visualisation of GPCR interactions in MD trajectories
Rasmus Fonseca, Stanford University

11:45-12:00 Status of GPCRmd simulation project
Jana Selent, Pompeu Fabra University, Hospital del Mar Medical Research Institute

12:00-12:20 Homology models
Gaspar Szekeres, University of Copenhagen

12:20-12:35 GPCR solvation
Eduardo Mayol, Universitat Autònoma de Barcelona

13:45-14:00  Registration

14:00-14:30 Welcome
Meriem Lamghari, INEB – Instituto de Engenharia Biomédica, i3S-Instituto de Investigação e Inovação em Saúde, Porto
Peter Kolb, Dept. of Pharmaceutical Chemistry, Philipps-Universität Marburg

Chairs: Daniela Sousa, Michael Boesgaard

14:30-15:05 Voltage dependence of muscarinic receptor signaling
Andreas Rinne, Institute of Physiology, Ruhr-Universität Bochum

15:05-15:40 Metabotropic mechanosensing through an Adhesion GPCR
Nicole Scholz, Rudolf-Schönheimer-Institute of Biochemistry / Dept of General Biochemistry; Faculty of Medicine / University of Leipzig

15:40-16h:40  Coffee break

Chairs: Christos Karoussiotis, Alba Salgado

16:40-17:25  Identification of a new highly TSH-receptor-selective small molecule inhibitor
P. Marcinkowski, Leibniz-Institut für Molekulare Pharmakologie, Germany

Flareplot: interactive visualization of residue interaction network dynamics in GPCRs
Rasmus Fonseca, Stanford University, EUA

Unraveling the mystery of the seemingly too short linker of bivalent ligands acting on opioid receptors
K. Pluhackova, Computational Biology, Department of Biology, Friedrich-Alexander University of Erlangen-Nürnberg, Germany

19:00 Drinks at the Palácio da Bolsa

30 March 2017

08:30-09:00 Registration

Chairs: Daniel Mayer, Madia Stama

09:00-09:35 Glowing pharmacology: insights from imaging GPCR ligand binding and dimerisation
Nick Holliday, Cell Signaling Research Group, School of Life Science, Nottingham University

09:35-10:10  The use of optical probes to reveal G-protein coupled receptor signaling in real time
Carsten Hoffmann, Dept of Pharmacology and Toxicology, University of

10:10-11:00  Coffee break

Chairs: Thu Phuong Tran, Aleksandra Luginina

11:00-11:45 Spectral tuning of light-sensitive GPCRs towards finer optogenetic regulation
Eshita Mutt, Laboratory of Biomolecular Research, Paul Scherrer Institut, Switzerland

Identification of nanobody derived peptides stabilizing functional conformational state of the β2-adrenergic receptor (β2AR)
Milka Vrecl, Institute of Anatomy, Histology & Embryology, Veterinary Faculty, University of Ljubljana, Slovenia

Highly designed combinatorial fragment growing coupled with parallel synthesis: Application to the discovery of novel ligands for the β2-adrenergic receptor
F. Chevillard, Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Germany

11:45-12:15 Poster teaser session / Rapid-fire presentations

12:15-14:00 Lunch & Group Photo

14:00-15:00 Management Committee meeting

15:00-16:30 Poster Session I (POSTER NUMBERS 1-35)

16:30-17:00 Coffee break

17:00-18:30 ERNEST meeting | Planning meeting for application of next COST Action, ERNEST: European Research Network on Signal Transduction


20:00   Dinner at Herança Magna Restaurant

31 March 2017

Chairs: Maiju Rinne, Florian Koensgen

09:00-09:35 Activation mechanisms of chemoattractant GPCRs: Chemokine receptors and the oxysterol receptor EBI2/GPR183
Mette Rosenkilde, Molecular Pharmacology Laboratory, University of Copenhagen

09:35-10:10 Single-cell profiling of GPCR expression in the vascular and immune system
Nina Wettschureck, Max Planck Institute of Vascular Biology

10:10-10:30  Coffee break

Chairs: Olga Prokopets, Ana Abreu

10h30-11:05 Vascular regulation by mechanosensitive GPCRs
Thomas Gudermann, Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München

11:05-12:30  Poster Session II (POSTER NUMBER 36-69)

12:30-14:00  Lunch

Chairs: Noureldin Saleh, Cecília Alves

14:00-14:35 GPCR structural cheminformatics: Navigating chemical and structural receptor-ligand interaction space
Chris de Graaf, Division of Molecular Toxicology, Free University of Amsterdam

14:35-15:10 Monitoring GPCR Signaling – From Single Cells to Single Molecules
Horst Vogel, Swiss Federal Institute of Technology, Lausanne

15:10-15:45 Uncovering multiple sites for GPCR modulation
Robert Cooke, HEPTARES therapeutics, Hertfordshire

15:45-16:15  Coffee break

Chairs: Linn Evenseth, Mariama Jaiteh

16:15-16:45  A common binding site for orphan receptor GPR139 agonists
Willem Jespers, Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Sweden

Selectivity determinants of GPCR-G protein binding
T Flock, MRC Laboratory of Molecular Biology / Fitzwilliam College, Storey’s Way, University of Cambridge, UK

16:45-17:30 Awards & Closing Session